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KMID : 0378120030300010121
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Chungnam Medical Journal
2003 Volume.30 No. 1 p.121 ~ p.128
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A Comparison of the Effect of Nalbuphine-Ketorolac and Butorphanol-Ketorolac for Postoperative Analgesia with the Use of IV-PCA
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Yoon Seok-Hwa
Lee Won-Hyung
Son Soo-Chang
Shin Yong-Sup
Kim Yoon-Hee
Yang Sin-Young
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Abstract
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This study aimed to compare analgegic efficacy, satisfaction score and side effect of nalbuphine-ketorolac and butorphanol-ketorolac by using intravenous patient controlled analgesia(IV-PCA) for postoperative anlgesia following a gastrectomy for stomach cancer. Ninety patients who had undergone gastrectomy for stomach cancer under general anesthesia were randomly divided into two groups. Each group recieived nalbuphine 50mg with ketorolac 150mg(Group 1, n=45) and butorphanol 5mg with ketorolac 150mg(Group 2, n=45) by using IV-PCA during postoperative 48hrs. Assessments for pain with numerical rating scale(NRS), and side effects were evaluated at 2hr, 6hr, 12hr, 24hr, 36hr and 48hr after the operation. There were no significant difference in NRS for pain during rest, but Group 2 requested significantly greater amount of supplementary diclofenac during first 24 hours. Side effects were higher Group 1 in pruritus, nausea and vomiting and Group 2 in sedation, nausea and vomiting. This study suggests that adding ketorolac with intravenous nalbuphine or butrophanol in using an intravenous PCA can decrease analgesics requirement and improve analgesic property without the major morbidity like respiratory depression, but needs for the careful observation and treatment on the side effects like nausea. vomiting, pruritis and sedation...
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KEYWORD
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Nalbuphine, Butorphanol, Ketorolac, IV-PCA
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